Extracorporeal membrane oxygenation (ECMO) is a complex life supporting procedure devised and developed for patients with pulmonary and/or cardiac complications. ECMO support serves as temporary lung and/or heart providing the required time for the patient’s organs to rest and recover. ECMO support is typically provided in a hospital’s intensive care unit (ICU) where a patient needs to be monitored 24/7. Therefore, ECMO specialists must undergo intensive training in order to be truly capable of preforming the appropriate action in time without threatening or endangering the patient’s live in the process. Moreover, one of the most complex and critical procedures in ECMO support is the cannulation process. Accordingly, without the proper training, proceeding with the process could lead to tragic outcomes. Therefore, training is significantly critical before attempting to provide ECMO support for a patient. Simulation-based training (SBT) is one of the most reliable and efficient approaches of training these days. SBT provides a hands-on experience for the trainee without threatening a patient’s life, which in time qualifies the trainee to work with real life critical situations. The aim of this project is to design and implement a life-like neonatal and pediatric ECMO cannulation simulators devised for training ECMO specialists to prepare them for real-life scenarios and complications that can be faced during ECMO cannulation procedure. The systems are designed to be effective, user-friendly, realistic, multi-functional, high-fidelity, and most importantly affordable. This report mainly focused on the design of the neonatal simulator, where all the designing steps and details are presented. However, the details of the pediatric simulator design are not presented, where it is concluded that the design will be closely based on the adult simulator presented in phase one of this project with modifications to fit the pediatric patient specifications. Therefore, the pediatric simulator will be designed after the neonatal simulator design is finalized. These systems are developed with the partnership of Hamad Medical Cooperation (HMC), the main healthcare provider in Qatar, to provide an effective way of training for doctors and trainees in Qatar. The team referred to HMC’s requirements while developing the design and visited the cooperation to collect information about the desired requirements and specifications.